Climate change and sustainable development have become critical challenges for global public health and healthcare systems. Kidney care, characterized by high resource consumption and carbon emissions, has emerged as a priority area for net-zero transformation. Shuang Ho Hospital launched the “Net-Zero Emissions Kidney Care Center” project, aligned with the United Nations Sustainable Development Goals (SDGs), which integrates digital transformation, low-carbon healthcare, circular economy principles, and disease prevention strategies. Through the Precision Kidney Digital System, the project enhances early diagnosis and comprehensive care, slowing disease progression and reducing resource use. Kidney transplantation advocacy and multidisciplinary integrated care further reduce dialysis dependence. To implement circular economy practices, the hospital introduced RO system wastewater recycling and dialysis waste reutilization programs, embodying the principles of green dialysis. In parallel, the hospital strengthened chronic kidney disease (CKD) risk stratification, community-based early interventions, and regional dialysis center alliances. By combining clinical quality, environmental responsibility, and social value, the initiative provides a practical model for advancing Taiwan’s healthcare system toward 2050 net-zero carbon emissions and sustainable development.