With advancements in medical technology, increasing attention has been paid to the occupational hazards faced by healthcare workers during endoscopic procedures. Physicians performing endoscopic surgery are prone to eye strain and visual impairment because of their prolonged screen time, and technicians responsible for reprocessing the instruments used in such procedures may be exposed to infectious aerosols. Common biological hazards include infections caused by pathogens such as Salmonella , Pseudomonas , Klebsiella , Enterobacter , Serratia and Staphylococcus , often resulting from the inadequate disinfection of endoscopes. Some microorganisms are particularly challenging to eliminate and may persist despite reprocessing, posing an ongoing risk to staff. Considering these threats, endoscopy personnel must adhere to standard precautions, particularly by minimizing contact with blood and bodily fluids. Despite the rapid advancements in endoscopic diagnostic and therapeutic technologies, the occupational exposure risks associated with these techniques are also increasing. Therefore, greater emphasis should be placed on the occupational safety and health of endoscopy personnel. Future efforts should include the development of standardized exposure reporting systems, protective protocols and routine health surveillance systems to create a safer working environment and ensure the well-being of those involved in endoscopic procedures.