目的：本專案旨在改善藥物基因提示訊息有效性，加強精準醫療照護品質。方法：針對藥物基因提示訊息有效性不足的問題，分析出11項真因，並提出「SAFE」四大對策群組，包括提升藥師認知（培訓種子藥師、持續教育）、優化提示訊息（整合訊息、強化關鍵資訊）、簡化系統設計（重點提示、阻擋高風險藥物開立）及建置查詢管道（平台與病歷整合）。結果：藥物基因提示訊息平均分數由2.6分提升至3.7分，達成率122%。藥物基因提示訊息有效性4分以上由21組增加至34組，達成率118%。結論：透過「SAFE」對策，成功提升藥物基因提示訊息的有效性與臨床實用性，並推廣至體系醫院。此成果可供其他參與TPMI計畫的團隊參考，提升精準醫療照護成效。

Purpose: This project was conducted to improve both the effectiveness of drug-gene interaction alerts and the quality of precision medicine care. Methods: The research team identified 11 root causes of inadequacy in drug-gene interaction alerts and proposed the SAFE framework accordingly. This framework has four strategies: (1)increasing pharmacist knowledge through seed pharmacist training and continuous education, (2)optimizing the content of alerts by emphasizing key information, (3)simplifying system design to highlight critical alerts and block high-risk drug prescriptions, and (4)establishing query channels that integrate digital platforms and medical records. Results: The average effectiveness score of alerts on drug-gene interactions increased from 2.6 to 3.7, for a target accomplishment rate of 122%. The number of alerts rated above 4 increased from 21 to 34, for a target accomplishment rate of 118%. Conclusion: The SAFE framework improved the effectiveness and clinical utility of drug-gene alerts and was expanded to affiliated hospitals. The project outcomes provide a valuable reference for other teams participating in the Taiwan Precision Medicine Initiative, boosting care quality in precision medicine.