“Safe healthcare and comprehensive quality control” is a core principle of hospital clinical care. This project aimed to improve the quality of care by optimizing the nutritional information system to enable automatic screening of refeeding syndrome (RFS) risk and the implementation of comprehensive medical orders for prevention. Based on international guidelines for RFS risk factors and stratification, the existing nutritional screening system was enhanced. Following consensus within the medical team, standardized order sets, handover procedures, and educational materials were developed, and a comparative analysis of data before and after the intervention was conducted. Results showed that the RFS detection rate by healthcare professionals increased from 49.2% to 81.8%, and the rate of medical order interventions prior to dietitian consultation increased from 63.1% to 90.9%. The proportion of patients with normalized electrolyte levels after nutritional intervention improved from 21.5% to 45.5%. By optimizing the nutritional care process for RFS, this project established the nation’s first automated RFS screening system, reducing the risk of RFS and achieving the goal of prevention over treatment, thereby enhancing the overall quality of clinical nutrition care.