This study designed a group mindfulness program for college students with interpersonal disturbances and examined the effectiveness of the program. The program consisted of six 120-min sessions held once a week. Because participants were experiencing interpersonal disturbances, the study relied on a one-group, pretest–posttest design. In total, 8 college students participated in the study. The Taiwanese version of the Five Facet Mindfulness Questionnaire and the Inventory of Interpersonal Problems were adopted and used to evaluate the outcomes of the program. The study involved 4 evaluations. Data were analyzed using the Wilcoxon signed-rank test. The degree of mindfulness among participants improved. Four mindfulness indicators had significant immediate intervention effects. The degree of mindfulness and observation had a significant delayed effect. Further, the degree of interpersonal disturbances improved. The three indicators of interpersonal disturbances also had significant immediate intervention effects. The program was deemed effective.