The context and framework of Education 4.0 are established from the application of teaching in ICT, the integration of interdisciplinary knowledge fields, the cultivation of students' learning and learning skills, the use of auxiliary education tools, and the educational application of big data analysis. The update, innovation and transformational thinking of university education leaders needs leaders to reflect on self-renewal to promote leadership enhancement, create creativity and creative culture to encourage innovation, and pursue multiple transformation methods to increase value. For Education 4.0, the integration of university leadership thinking mode can be embodied in the integration of global technology and learning, open and effective online teaching courses are established, education leadership and technology integrate interdisciplinary knowledge fields, population and Industry 4.0 needs transform the implementation of the university’s education system. The role and leadership abilities of leaders and teachers are jointly cultivated and improved. The cultivation of student learning must be imported from the self-leadership ability of students. Leaders are based on the educational needs of human nature and the ability to make good use of artificial intelligence. Platforms and channels, operating and creating a high-quality teaching and learning Internet environment.