Science learning today places great importance on students’ problem-solving skills in real life situations, and as a result, interdisciplinary teaching and learning have become increasingly essential. At present, however, instructional design and the development of teaching materials in this field are still growing and require the practice of teacher preparation. Consequently, a two-credit, inquiry- and practice-based course was offered for undergraduate students in this research with the aim of cultivating maker teachers in terms of fostering maker abilities. Seventeen participants in the course learned how to operate and apply a 3D printer to create some works to solve specific problems in people’s daily life; and at the end of the semester, they displayed their creations and elaborated upon the problem-solving process. An online learning platform was established during the course to provide learning assistance and to make data collecting and sharing more feasible. A qualitative approach and a thematic analysis method were implemented to analyze data that were respectively derived from three dimensions of self-regulated learning (SRL) as well as meta-knowledge. The main findings in the research include: 1. Experience plays a central role in the formation of individual cognition; 2. In a material-limited learning environment, there is still room for improvement for pre-service teachers to choose topics or to evaluate the feasibility of the topics; 3. In the process of imitation, even though the teachers behave as consultants and do not teach relevant skills, the creative meta-knowledge of pre-service teachers could be enhanced; and 4. From imitating to creating, the pre-service teachers show the realization of their deficiencies in the beginning and practice self-regulated learning during the process. The findings show both individual and social factors play important roles in task completion.