代謝症候群與其相關因子之研究－－健檢資料分析

A Study on Related Factors of the Metabolic Syndrome: Based on Health Screening Data

代謝症候群的重要性是其可預測未來發生第二型糖尿病及心臟血管疾病，因此代謝症候群操作性定義之出現，對預防醫學而言，提供了一大利器。目前之研究發現有些實驗室檢查結果與胰島素阻抗性及慢性次臨床炎症有關，可見其可能亦與代謝症候群有相關。本研究從2004年3月至12月間，以台中市某區域醫院自費健康檢查之成人居民為對象，分析某些自費健康檢查常用的實驗室檢查結果與代謝症候群的關聯性，共收集有效樣本821人，其中男性有520人(63.3%)。結果顯示符合代謝症候群標準者有178人(21.7%)，其中男生有118人(22.7%)，女生有60人(19.9%)。基本資料及實驗室檢查與代謝症候群之關聯以卡方檢定，結果發現年齡、身體質量指數、腹部肥胖、肝膽功能、腎功能及尿酸指數與代謝症候群之相關達統計學上的意義，但總黃膽指數與代謝症候群呈負相關。進一步以逐步邏輯斯複迴歸分析，結果發現年齡越大、有抽菸習慣者、丙胺酸胺基轉化酶、高尿酸血症異常者、身體質量指數越大者與代謝症候群呈正相關，而總黃膽指數與其呈負相關。因此，在健檢中發現有抽菸習慣、年齡較大、身體質量指數較大者、或有丙胺酸胺基轉化酶及尿酸異常者，除了例行性處置外，建議應注意其是否有符合代謝症候群之危險指標。

The importance of the metabolic syndrome is to predict the intentioned development of type 2 diabetes mellitus and cardiovascular disease, so does its working definition to the career of prevention medicine. Some laboratory data revealed the association of insulin resistance and chronic subclinical inflammation with the metabolic syndrome, so they could be associated with the metabolic syndrome. The aim of the present study was to analyze the association of some common used laboratory data with the metabolic syndrome from March to December 2004 from the residents of health inspection of a regional hospital at Taichung. A total of 821 subjects with 63.3% male were analyzed. There were 178 subjects (21.7%) with 118 male (22.7%) and with 60 female (19.9%) matched the definition of the metabolic syndrome. Chi-square analyzed the association of demographic data with the metabolic syndrome, the result revealed age, body mass index, abdominal obesity, hepatobiliary enzyme, renal enzyme and uric acid being associated with the metabolic syndrome, but it was negative correlation of total bilirubin. Stepwise multiple logistic regression further analyzed age, body mass index, smoking, alcohol consumption and laboratory data with the metabolic syndrome, it revealed those who were elderly subjects, smoking, abnormal alanine aminotransferase, high uric acid, and increased body mass index were positive correlation with the metabolic syndrome, but total bilirubin was negative correlation with it. Besides normal treatment of the diseases, doctors should care more about the related markers of the metabolic syndrome, if they were the ones of above mentioned abnormal data found at health inspection department.