This study administered an interview-based questionnaire survey involving 102 primary family caregivers of middle-aged and older individuals with intellectual disabilities to examine the relationship between family quality of life (FQOL) and coping strategies. Results indicated that overall family FQOL was at a moderately satisfactory level, of which satisfaction with physical/material well-being was the highest domain and satisfaction with disability-related support was the lowest. Caregivers predominantly adopted self-regulation strategies and sought external assistance only if necessary. Lower FQOL was associated with multiple disabilities of the care recipient, lower household income, and a tendency for caregivers to adopt withdrawal or avoidance coping strategies. Contrastingly, the use of positive self-regulation strategies was associated with improved FQOL. The findings suggest that positive cognitive and emotional regulation contributes to improved FQOL. Because of the cross-sectional design and non-random sampling, the results have limited generalizability and causal relationships cannot be established.