隨著新冠肺炎(COVID-19)轉向常態化流行，季節性流感在邊境解封後再度活躍，全球醫療體系正迎來「雙重流行」的嚴峻挑戰。這兩種呼吸道病毒在傳播途徑、臨床表現及高風險族群上具有高度重疊性，增加醫療機構在診斷辨識、病人分流與院內感染管制的複雜度。本文旨在從臨床實務與醫療品質管理角度，探討在雙重流行期如何透過精準篩檢、高風險族群識別、環境管理、醫護人力保護及推動疫苗接種等面向，建立適當的感染治療及堅韌的感染管制防線，確保病人安全及醫療量能維持。

With COVID-19 transitioning into an endemic phase and seasonal influenza resuming active transmission following the reopening of borders, healthcare systems worldwide are facing the challenge of the co-circulation of COVID-19 and infuenza. COVID-19 and infuenza share similar transmission routes, clinical manifestations, and high-risk populations, which increases the complexity of diferential diagnosis, patient triage, and healthcare-associated infection control. This article examines infection control strategies during this co-circulation from the perspectives of clinical practice and healthcare quality management. Key approaches include precise screening, early identification of high-risk individuals, environmental management, protection of healthcare workers, and promotion of vaccination. Through these multidimensional measures, healthcare facilities can support effective clinical management and establish a resilient infection control framework, thereby ensuring patient safety and maintaining healthcare system capacity.