In recent years, the issue of depression among adolescents has become increasingly severe, necessitating more diverse and effective methods of assessment and intervention. While adolescent autonomy and depression have long been considered closely related, there is still a lack of empirical research to support this notion. Furthermore, past research on autonomy has predominantly used Western concepts, directly applying them to subjects from different cultures, which can lead to cultural bias and fail to provide accurate and effective local reference data. In light of this, this paper adopts the "dual autonomy model," which is supported by empirical research and is suitable for local culture, to further explore the issue of depression among Taiwanese adolescents. After comparing the dual autonomy concept with the DSM-5 criteria for depression and the Beck Depression Inventory, it was found that the latter two only assess the internalizing problems of adolescent depression (cognitive, emotional, behavioral, and physiological) but overlook important externalizing problems (interpersonal adaptation). These externalizing problems are closely linked to the cultural characteristics in which adolescents grow up. Based on these findings, the following recommendations are proposed: (1) Research Aspect: Primarily establish localized data, including examining the correlation between dual autonomy and adolescent depression, and clarifying the differences between individual autonomy and relational autonomy in diagnostic assessment. Conduct interviews with depressed adolescents to gain an in-depth understanding of the connections and corresponding content between adolescent depression, autonomy development, and the social and cultural contexts they live in, especially concerning Chinese values of filial piety and parenting beliefs. (2) Practical Aspect: Develop assessment tools or systems for evaluating the interpersonal adaptation of adolescents with depression. Integrate cultural characteristics into counseling interventions. For example, during the counseling process, consider the unique family values and interpersonal relationship patterns in Chinese culture.