目的：探討膝伸肌群預先進行一回合最大等長收縮（MVIC）後，2天後再進行次回合60次最大離心收縮運動（MAX-ECC）誘發肌肉損傷後，其肌肉損傷指標與脈波傳導速率的變化。方法：招募16名健康男性為研究對象，隨機分派至運動組與控制組，運動組先進行一回合膝關節彎曲120度MVIC 2天後，進行次回合60次（10次／組×6組）角速度30°／s的MAX-ECC誘發肌肉損傷，控制組僅進行MAX-ECC。依變項為最大自主等速向心收縮肌力（ISOK）、關節活動角度（ROM）、肢體圍（CIR）、頸股動脈波傳導速率（cfPWV）、舒張壓（DBP）、收縮壓（SBP）及心跳（HR）。於初回合MVIC的前測、運動當天、後1天，以及2天後次回合MAX-ECC的前測（Pre）、運動當天及後5天進行依變項的測驗。結果：運動組進行預先2次MVIC後，ISOK、ROM、CIR及cfPWV皆未產生顯著變化（p > .05），經過2天再進行MAX-ECC後，兩組之間的肌肉損傷指標與血管功能指標無顯著差異（p > .05），ISOK在運動組及控制組分別自後測的0－2及0－3天顯著低於前測（p < .05），兩組的ROM及CIR，前測皆與後測0－5天達顯著差異（p < .05）。在cfPWV，兩組皆於前測與後測1－2天達顯著差異（p < .05）；兩組在DBP、SBP及HR，皆在前後測的天數無顯著變化（p > .05）。結論：預先以非慣用腳膝伸肌群進行2下MVIC無引起明顯的肌肉損傷，在針對隨後第2天進行的MAX-ECC無法產生保護效果，亦法無法降低cfPWV。

Purpose: This study was to investigated the protection of the knee extensors by performed first bout of maximum volun-tary isometric exercise (MVIC), and then undergo second bout of 60 maximal isokinetic eccentric concentric (MAX-ECC) after two days. Methods: Sixteen healthy males were randomly assigned either to the MVC group and CON group. After MVC group performer the first bout of MVIC (2 times, 120°flexion), MVC and CON group had performed MAX-ECC 60 times (10 times/set×6 sets) in second bout after 2 days. The dependent variables include measured maximal isokinetic concentric strength (ISOK), range of motion (ROM), limb circumference (CIR), carotid-femoral pules wave velocity (cfPWV), diastolic blood pressure (DBP), systolic blood pressure (SBP) and heart rate (HR). These variables were measured the pretest (pre), im-mediately after (D0), after MVIC (D1) in the first bout. The second bout were measured the pretest (pre), immediately after (D0), and on the first day to the fifth day (D1~D5, every 24 hours). Results: No significant changes in ISOK, ROM, CIR and cfPWV after MVIC (p > .05). After finished MVIC two days later, ISOK of the MVC group were significant lower than pretest at D0~D2, ISOK of the CON group were significant lower than pretest at D0~D3. ROM and CIR of the both group were signifi-cant difference with pretest at D0~D5 (p < .05), and cfPWV of the both group were were higher than pretest at D1~D2 (p < .05). Conclusion: Preconditioning knee extensor muscles with 2 MVIC does not cause abundance muscle damage, and also not cause RBE by subsequent MAX-ECC, cfPWV still induced by subsequent MAX-ECC.