Background: With the global trend of population aging and increasing chronic diseases, there is a growing emphasis on Hospital at Home (HaH) models to allevi-ate the burden on healthcare systems and improve care efficiency. This study aims to explore the preliminary implementation and outcomes of acute care at home in a regional hospital in northern Taiwan. Objective: To analyze the sources of enroll-ment, indications, treatment outcomes, and post-discharge follow-up of patients en-rolled in the acute home care program from July 2024 to March 2025, and to evalu-ate the feasibility and effectiveness of home-based acute care as an alternative to hospitalization. Methods This retrospective study collected data from 17 patients who met the criteria for acute home care enrollment. Patient demographics, care processes, treatment outcomes, and emergency department visits or hospitalizations within 3 and 14 days post-discharge were analyzed. Results: A total of 17 patients (7 males and 10 females) were enrolled, with a mean age of 78.2 ± 9.2 years. The ma-jority of patients (52.9%) were residents of care facilities. The most common indi-cation for enrollment was urinary tract infection (88.2%). Among all cases, 88.2% achieved clinical resolution and were referred back to their original medical teams. No patients required emergency visits or hospitalization within 3 or 14 days after discharge, aligning with the national health insurance data. One case (6.67%) ex-ceeded the target treatment duration due to the need for extended antibiotic therapy for soft tissue infection. Conclusion: The results suggest that acute home care can effectively control infections without increasing the risk of emergency department visits or hospitalization. Successful implementation requires stable patient vital signs, clear treatment plans, flexible clinical decision-making, and comprehensive support for patients and families. Home-based acute care could serve as a viable al-ternative to traditional inpatient care.