This study examines the impact of health literacy and patient empowerment on doctor-patient relationships. Utilizing data from multiple sources, this paper outlines how patients acquire information about diseases and care to empower themselves to self-help and assist others. Data sources include colorectal cancer diaries on social media, colorectal cancer-related information from major hospital websites, in-depth interviews with hospital nurses, colorectal cancer patients and their families, and participatory observation records of online colorectal cancer patient communities. This study suggests that health care providers should encourage and enhance interactive and critical aspects of disease knowledge. Patient and public empowerment requires active and passive engagement in the management and sharing of physical, mental, and disease experiences. This enables patients to obtain information and experiences about diseases and treatments through various communication channels, positioning healthcare providers as consultants, advisors, and sharers. Consequently, shared decision-making in doctor-patient relationships becomes a possibility.