Purpose: This study examined the impact of implementing a multidisciplinary Team Resource Management (TRM) care model on quality and patient safety in chemotherapy care for patients with gynecologic cancer. Methods: A TRM-based care model was implemented for patients receiving chemotherapy for the first time. Multidisciplinary team members, including nurses, dietitians, and pharmacists, provided patients with profession-specific information. After discharge, patients reported symptoms experienced at home using an online platform linked to a messaging application, the Gynecologic Cancer Caregiver Artificial Intelligence Platform. The platform enabled continuous monitoring of recent treatment-related adverse effects and facilitated timely health education and care interventions by case managers. Results: The TRM care program was provided to 94.7% of patients receiving chemotherapy. Within two days, 100% of patients received profession-specific education from the multidisciplinary team, with an average education time of 63 minutes. After discharge, 84.2% of patients used the online side-effect reporting system, enabling case managers to identify patient concerns more promptly. Conclusion: A multidisciplinary TRM care model enabled the delivery of professional, timely, and personalized education, thereby improving chemotherapy care quality and patient safety for patients with gynecologic cancer.