Residents in long-term care facilities are primarily older adults and individuals with chronic illnesses. Due to weakened immune systems and the communal nature of their living environments, they are at particularly high risks of contracting infectious diseases. Personal protective equipment (PPE) is one of the most fundamental and critical measures in infection prevention and control, and its proper use and management directly determine the effectiveness of infection control within facilities. Infection control nurses play a vital role in ensuring that protective measures are fully implemented in clinical care settings through comprehensive approaches encompassing risk assessment, education and training, monitoring and auditing, and system development. Current observations indicate that while most long-term care facilities are equipped with basic PPE such as gloves, surgical masks, gowns, face shields, and goggles, common issues persist, including nonstandardized usage procedures, incorrect donning and doffing steps, insufficient training frequency, and inadequate resource management. These problems not only reduce the effectiveness of protection but also increase the risk of cross-infection within facilities. To strengthen infection prevention capacity, staff education on infection control should be enhanced, standardized operating procedures for PPE use should be established, and regular audits along with real-time feedback mechanisms should be implemented to ensure both accuracy and consistency in protective practices. Infection prevention and control (IPC) nurses and nursing staff play a pivotal role in long-term care facilities, not only supervising the implementation of protective measures but also fostering a culture of infection prevention. Through systematic management and continuous education, facilities can effectively reduce the incidence of infectious diseases, safeguard the safety of residents and caregivers, and improve the overall care quality.