Bloodstream infections (BSI) represent a major category of healthcare-associated infections. This medical condition is characterized by high mortality and an increased risk of prolonged hospitalization, particularly when associated with the use of central venous catheters (CVC). To enhance detection efficiency and the speed of clinical response, artificial intelligence (AI) technologies have been widely introduced into infection surveillance, prediction, and decision-support systems, emerging as a new trend in healthcare quality management. Internationally, institutions such as Mayo Clinic and Kaiser Permanente in the United States have developed AI algorithms capable of automatically analyzing electronic medical records and laboratory data to identify high-risk cases of central line-associated bloodstream infection (CLABSI), thereby providing real-time clinical alerts. In Asia, countries including Singapore and South Korea have incorporated natural language processing (NLP) and surveillance models into clinical record systems, which has effectively improved the accuracy of risk prediction. In Taiwan, the medical community has also progressively expanded the application of AI in infection control. For example, emergency departments have implemented a “sepsis AI model” to rapidly stratify patients by sepsis risk levels, enabling physicians to respond promptly. Hospitals have also integrated data from electronic medical record systems and applied the Taiwan Centers for Disease Control’s definitions for healthcare–associated infection (HAI) into AI systems to assist in case determination, thereby improving timeliness and enabling earlier clinical interventions with appropriate infection prevention and control measures. In addition, surveillance results have been visualized using the Power BI platform, facilitating the presentation of HAI trends, supporting review and analysis, and providing rapid, accurate feedback to guide infection control decision-making. In the future, the integration of AI prediction models, rapid microbial diagnostics, and standardized care pathways will contribute to the establishment of a more efficient, safer, and cost-effective infection management system, thereby continuously enhancing the quality of clinical care.