Objective: To improve clinical outcomes and reduce medical costs, this study aimed to establish a standardized nutritional intervention model for the early detection of poor nutritional status among hospitalized older patients. Methods: Hospitalized patients in the geriatric ward of a medical center in central Taiwan were received nutritional interventions. Nutritional status was assessed using the Malnutrition Universal Screening Tool (MUST) and the Mini Nutritional Assessment (MNA) , and individualized nutritional interventions and follow-up were provided by a multidisciplinary team consisting of physicians, dietitians, and nurses. Results: The percentage of older patients with adequate nutritional status increased from 46% to 96% after the intervention. Medication reconciliation was associated with reduced functional decline, enhanced caloric and protein intake, improved nutritional status, better quality of life, and greater dietary diversity. Conclusion: Following project optimization, the overall goals of improving clinical outcomes and reducing medical burden were achieved.