抗生素抗藥性已成為全球性公共衛生危機，對人類與動物健康、食品安全及環境等多層面構成嚴峻挑戰。為降低抗生素抗藥性威脅，強化政府部門醫藥、食品、農業等三方跨單位合作，衛生福利部疾病管制署、食品藥物管理署及農業部自2025年起共同推動「國家級防疫一體抗生素抗藥性管理行動計畫」，以防疫一體(One Health)為架構，透過「建立和發展國家抗生素管理協調機制」、「確保動物用、人用之抗生素源頭及流向管理」、「提高民眾及醫療專業人員認知」、「優化醫療照護感染預防和控制」、「推動抗生素抗藥性整合性共同監測與風險評估機制」5大策略，強化我國抗生素抗藥性防治及減緩抗生素抗藥性之發生及傳播。未來將持續強化跨部門協作機制，並透過國家抗生素抗藥性管理核心能力評核，盤點尚待精進之處，俾據以強化各相關部門跨域因應作為。

Antimicrobial resistance (AMR) has become a global public health crisis, posing severe challenges to human and animal health, food safety, and the environmental domains. To address the threat of AMR and strengthen interdepartmental collaboration among the health, food, and agricultural sectors, the Taiwan Centers for Disease Control and Taiwan Food and Drug Administration under the Ministry of Health and Welfare, in partnership with the Ministry of Agriculture, have jointly launched the "National One Health Action Plan on Antimicrobial Resistance, 2025–2029" . Based on the One Health framework, the action plan outlines 5 key strategies: (1) establishing and strengthening a national coordination mechanism for AMR management, (2) ensuring sources and supply chain management of antimicrobials in both human and animal use, (3) increasing awareness among the public and healthcare professionals, (4) enhancing infection prevention and control in healthcare settings, and (5) implementing integrated surveillance and risk assessment mechanisms for AMR. These strategies aim to strengthen AMR prevention and control in Taiwan and to reduce the occurrence and spread of AMR. Moving forward, interdepartmental collaboration mechanisms will be further reinforced. In addition, evaluations of national core capacities for AMR management will be conducted to identified gaps and inform cross-sectoral improvements.