This study explores the causes and coping strategies of students’ learning difficulties in multicultural ethnic groups in national primary schools, and the current situation and relationship between teachers’ resilience and teachers’ well-being in the context of students’ learning difficulties. A total of 13 teachers from 6 schools in New Taipei City and Taoyuan City were selected. The results show that: 1. In the context of the learning difficulties of students from multicultural ethnic groups, teachers’ resilience includes: positive emotion management, good interpersonal relationships, situational and resource support, improved professional growth, job achievement satisfaction, and good parent-teacher communication. 2. Strategies for teachers to improve their well-being include: making good use of successful experience incentives, teamwork and team support, professional identity and professional improvement, positive traits and sense of mission, as well as continuous self-transcendence and reflection. 3. Under the learning dilemma of students from multicultural ethnic groups, improving teachers’ resilience can effectively improve teachers’ well-being, and the two have a direct mutual impact.