Difficulty in evaluation is considered due to the high-rise building of the hospital, the complicated electrical piping, and the fact that patients during hemodialysis are limited by the dialysis machines. A fire drill was conducted in August 2020, and the evacuation time was 28 minutes and 17 seconds. It is higher than the 21 minutes stipulated by the fire department. Therefore, a task force was formed to make improvements. After analyzation, we found several problems to be solved. First of all, patients had not participated in actual fire evacuation drill. Second, the evacuation routes were not clearly marked. Third, patients’ understanding was not adequately evaluated after our health education guidance. Fourth, the relevant health education guidance tools were insufficient. The implementation period is from September 1, 2020 to January 31, 2021, for a period of 5 months, in three stages: planning period, implementation period and evaluation period. Therefore, improvement measures was conducted, including holding actual fire drill with emergency evacuation, making luminous evacuation sign for escape routes, regulating auditing standards of cognitions and skills for evacuation, making emergency evacuation photocards, health education guidance leaflets and videos, and establishing operationg procedures of dialysis equipment separation. After the implementation of the project, the cognition improvement of patients about the emergency evacuation of fire was from 42.0% to 88.4%, and the skills of evacuation was from 38.9% to 88.0%. Furthermore, the evacuation time shortened from 28 minutes and 17 seconds to 19 minutes and 50 seconds. Eventually, it is more helpful for patients to ensure their own safety in the event of a fire.