This article described the nursing experience of a woman with low life quality withdrawing from dialysis. The author collected all the data through holistic assessment, observation, continued conversation and medical records from April 20, 2020 to May 10, 2022. We detected patient’s nursing problems, such as: excessive body fluid volume, psychological distress, and death anxiety. Although the patient clearly chose palliative care, she still felt anxious and helpless when facing death. The nursing process provided medicine and non-medicine method, to reduce the patient’s symptoms well controlled; giving care, empathy, and respect to her will, helping her participate in the palliative care decision-making and overcome depression and conflicting emotions, as well as providing nursing intervention through cross-disciplinary cooperation and religious activities to achieve her spiritual comfort. We encouraged the patient and families to express their love, thanks, apology, and farewell to each other, helping to arrange things before passing away to be good at dying and resolve the health problem of anticipatory grief and anxiety.