This article describes the care of a young adult male long-term hemodialysis patient. The patient was concerned about the efficacy of cancer treatment due to multiple side effects after multiple cancer recurrences and target drug therapy, which resulted in dose reduction and drug discontinuation. In addition, the patient also had a problem of facing the uncontrollable future of life and his continuous pessimistic attitude attracted the author’s attention. From January 04 to February 26, 2021, the author conducted a comprehensive assessment of the physiological, psychological, social and spiritual aspects, and employed through observation, medical history review, physical evaluation and interview, to confirm that the patient had “potential risk of bleeding”, “diarrhea” and “sense of hopelessness”. During the period of hemodialysis, the author actively cared for the patient, used listening and body language to increase the trust of the patient, and learned the lifestyle habits of the patient, clarify the doubts and uneasiness about the disease and the future life of the patient and coordinated with medical team members and patient groups, to enhance the patient’s understanding of the treatment of the disease and search for the different meaning of life. This reduced diarrhea and potential bleeding-related problems, which enhanced the self-awareness and control of the disease by the patient. It is suggested that psychological assessment should be added to the outpatient follow-up, so as to promptly determine whether patients have emotional distress through specialist examination.