This article describes the nursing experience of a hemodialysis patient with PAOD receiving below-knee amputation. The appearance and structural changes of the amputated limb had a huge psychological impact and shock. The nursing period was from April 8 to June 30, 2021, using Gordon’s 11 Functional Health Patterns were to collect information through direct care, observation, medical records and interviews. Identified problems included inadequate nutrition, impaired physical mobility and body image disturbance. During the nursing process, provided individualized nursing, designed protein exchange recipe guided by QR code, monitored his nutritional status and taught his family after amputation care skill. The author performed active caring and accompanied him to guide him express his deep mind feelings and to encourage his family to give support and accompany. Medical professionals should actively help amputees face irreversible complications, enhance their knowledge and self-care skills, rebuild positive attitudes, regain self-control and move forward to a new life.