This article describes the patient’s poor quality of life owing to hemodialysis hypotension. He felt a sense of loss of motor control. Because of his chronic disease that mandated continued hemodialysis, the patient felt hopeless. Have caused the author’s motivation. During the nursing period from September 2 to October 28, 2019, the author used Gordon’s 11 functional health assessment tools to collect subjective and objective data to establish the patient’s health complications, such as excess fluid volume, constipation, and hopelessness. For physiological improvement, the patient was educated of water intake regulation, daily weight measurement for effective weight control between 2 dialysis sessions, and use of drug- and non-drug methods to help develop a daily bowel habit. For psychological support, the Beck Hopelessness Scale was used as a mental state assessment tool. Family support and nephrologist’s sharing of their experience were used to help the patient overcome the challenges from hemodialysis. Basis this study, we recommend establishing effective strategies to cope with disease, improving the individual’s sense of control over life and encouraging active participation in treatment, successfully adapting to the changes in daily life effected by hemodialysis, and expressing expectations and plans for the future.