This article describes the nursing experience of a patient suffering from end-stage renal disease undergoing peritoneal dialysis for the first time because of catheter leakage caused by wound skin discomfort and anxiety. The nursing period is from January 2 to March 8,2019.The author used Gordon’s eleven health function assessments as a guide to collect data and analyze through direct care, interviews, observations, and medical records. The problems are as follows: Health problems such as nutritional status less than what the body needs, potentially dangerous infections and anxiety. During the nursing process, consult a nutritionist and use the mobile phone APP and Health Education Leaflet and video to enhance the cognition of dialysis diet, so as to improve the nutritional status; assist in guiding the care of catheter wounds, follow the principle of aseptic techniques, and avoid skin damage to prevent infection;Take active care, encourage patient present inner feelings, cooperate with the doctor to explain the procedure again to increase confidence, teach relaxation techniques and massage with essential oils to reduce anxiety. I hope that this care experience can provide a reference for clinical care of similar cases.