血清尿酸值在中老年族群中與骨密度之相關性： 一篇回溯性橫斷式研究

Associations between Serum Uric Acid Level and Bone Mineral Density in Older Adults: A Retrospective Cross-sectional Study

目的：隨著台灣人口快速老齡化和生活習慣的改變，骨質疏鬆症的盛行率日益增加，可能嚴重影響患者的生活品質，並且是重要的公共衛生問題。因此，尋找並理解造成骨密度降低的危險因素，對於預防及早期診斷骨質疏鬆症十分重要。本研究旨在探討血清尿酸與骨密度之間的關係。

方法：在2016年1月至2016年12月期間，本研究共納入2,564名接受過雙能量X光吸收儀骨密度掃描健康檢查的參與者。經過篩選條件排除後，共有1,540名大於等於50歲之個案被納入分析，本研究使用多元羅吉斯迴歸分析用於檢查血清尿酸值和骨質減少/骨質疏鬆症與結果的關聯性。

結果：簡單羅吉斯迴歸顯示血清尿酸值較高的族群其低骨質密度（包含骨缺乏或骨質疏鬆症）風險比較低(OR 0.82, 95% CI 0.76-0.88)。在亞組分析中，依據血清尿酸值進行分組並調整干擾變項後，血清尿酸值較高的族群仍有較低的低骨質密度風險。

結論：本研究發現在中老年族群中，血清尿酸值較高者其低骨質密度的風險較低。

 

Background/Purpose: The prevalence of osteoporosis is rising along the rapid population aging in Taiwan, posing a grave public health concern due to its negative impacts on the quality of life among older adults. Identifying and understanding the risk factors of decreased bone mineral density is therefore essential for osteoporosis prevention and early diagnosis. The study aimed to investigate the associations between serum uric acid (sUA) and bone mineral density.

Methods: Between January 2016 and December 2016, 2,564 participants who had undergone health examinations with a dual-energy X-ray absorptiometry scan were recruited. After exclusion, the study was conducted with 1,540 eligible subjects aged 50 years and order. Multiple logistic regression was used to examine associations of sUA and osteopenia/osteoporosis with outcomes.

Results: Participants with higher sUA levels had significant lower risk of osteopenia/osteoporosis in simple logistic regression (OR 0.82, 95% CI 0.76-0.88). On subgroup analyses, stratified by sUA level, groups with higher sUA still had lower risk of osteopenia/osteoporosis after adjusting for other confounders.

Conclusion: The study reveals that middle-aged and older adults with higher sUA levels had significant lower risk of osteopenia/osteoporosis.