Peritonitis will not only influence the efficacy of peritoneal dialysis (PD), but it is necessary to terminate PD treatment in severe cases. It has been reported that peritonitis-related deaths account for 15% of the mortality of PD patients. The project period is from April 1st to September 30th, 2019. The goal of this project is to implement multiple strategies to reduce the incidence of peritonitis. According to our present analysis, we found that the high incidence of peritonitis is due to incorrect execution and under-cognition of fluid exchange technique by the patient and main caregiver, no well-established timing of technical audits, lack of relevant health education guidance, reminder slogans and various health education aids. By revising the technical standards for PD fluid exchange, improving the accuracy of exchange technique, strengthening the awareness of peritonitis, increasing the timing of technical audits, making relevant health education leaflets and reminder slogans, using various health education aids and other improvement measures, the occurrence of peritonitis events dropped from 3.62 times/100 person-months to 1.55 times/100 person-months. In conclusion, this project used multiple strategies to reduce the occurrence of peritonitis, enhance self-care awareness and skills in PD treatment, and thereby improve the quality of PD care.