China’s expanding collaboration with the rest of the world entails an urgent need for significant professional talent with excellent intercultural communication skills. Guo and Gallo’s (2017) study reveals that a talent shortage has constrained China’s business development. Of all the challenges, language and culture are seen as the major threats for young business professionals when undertaking various roles in a global setting. The present study investigates language and cultural challenges that Chinese business professionals encounter in intercultural communication at work and examines the strategies that professionals apply in coping with these challenges. The semi-structured interview data were gathered from 11 interviewees to explore the challenges encountered, their reasons, and the strategies used to meet these challenges. The findings of this study can facilitate more effective ESP teaching/learning and business communication practice.