There were numerous garrisons (weisuo) under the Ming dynasty’s ‘bridle and halter’ administrative system scattered across the northeast territory beyond the Great Wall. One garrison among them incorporated three tribes and was known as the Wu-Liang-Ha Garrison. The Wu-Liang-Ha Garrison was under Ming rule, but it also had close connections with Mongolian rulers and functioned as an autonomous military unit. It became the influential force residing in greatest proximity to the Ming border and possessed the right to trade with the Ming. When in the sixteenth-century, the Yuan descendant Dayan Khan reunited Mongolia, including the Wu-Liang-Ha Garrison, the latter were still a vassal of the Ming court. The Duoyan Garrison became the leading force among the Wu-Liang-Ha tribes up through the early 17th century, yet its history has rarely been studied. The primary aim of this paper is to flesh out the origin and development of the Duoyan Garrsion after 1600 and adumbrate the role it played between the northern tribes and Ming China.