Background: Haematological malignancy affects lip id homeostasis representing elevated risks of cardiometabolic diseases. This study investigated the alteration of plasma lipids/lipoproteins and the underlying regulation mec hanism. Materials and Methods: B lood samples were collected fr om acute myeloid leukaemia(AML)patients pre- and post-chemotherapy and matched controls. Trigly ceride(TG), total cholesterol(TC), high-density-lipoprotein cholesterol(HDL-c), low-density-lipoprotein cholesterol(LDL-c)and apolipoproteins(apo)were quantified in plasma and lipoprotein-density-gradient f ractions. The cardiometabolic risks and lipid loads were assessed. Results: Dyslipidaemia was revealed in 75% of AML p atients pre-therapy by reduction of HDL-c and in 85% post-therapy by div erse combined patterns. Com pared to the controls, AML patients exhibited increased plasma TG and cardiometabolic risks both pre - and post-therapy. The plasma TC, HDL-c, apoAI, B-100, CIII and J were decreased pre-therapy but were re stored post-therapy. The plasma TG concentration was positively correlated with LDL-TG load, whereas plasma TC was positively correlated with HDL-c. Furthermore, the fractio nated very-low-density lipoprot ein(VLDL)-TG load was lower but LDL-TG load was higher in AML pat ients than in the controls, sug gesting that circulating TG hydrolysis might be impaired from VLDL conv ersion to LDL. Conclusion: The plasma lipid profiles in AML were a berrant and predicted high cardiometabolic risks, which might need further follow-up attentions.