This study employs a theoretical model, wind tunnel experiments and a Computational Fluid Dynamics (CFD) model to investigate the natural ventilation potential of residential buildings. The effects of wind direction, window screen, balcony, building length and adjacent buildings are considered by the present model. Then the model is employed to systematically investigate the natural ventilation of a residential building. The simulation results reveal that the ventilation rate of buildings with the internal doors closed is much smaller than that of building with all the windows and doors are open. In addition, the average air change rate, ACH, of the building under the natural ventilation condition can be used to assess the effectiveness of the natural ventilation for buildings cooling.