A Case of Breast Amyloidosis in a 70‑year‑old Rheumatoid Arthritis Patient

A Case of Breast Amyloidosis in a 70‑year‑old Rheumatoid Arthritis Patient

Amyloidosis of the breast is an exceptionally rare disorder characterized by extracellular amyloid deposition. We describe a 70‑year‑old woman with longstanding rheumatoid arthritis (RA) in whom routine mammography revealed new amorphous, grouped microcalcifications in the left breast without a palpable or imaging‑detectable mass. Surgical excision showed Congo red‑positive localized amyloid deposits, and systemic evaluation–including laboratory studies, electrocardiogram, and echocardiography–revealed no evidence of systemic amyloidosis or malignancy. The patient required no additional treatment and remained stable under periodic follow‑up. This case illustrates an unusual presentation of breast amyloidosis manifesting solely as microcalcifications, a finding reported only rarely and one that may mimic malignancy. Localized breast amyloidosis generally carries an excellent prognosis, underscoring the importance of histopathological confirmation and distinction from systemic disease, particularly in patients with chronic inflammatory conditions such as RA.