| 英文摘要 |
Objectives: Guillain–Barrésyndrome (GBS) is an uncommon but potentially life‑threatening peripheral neuropsychiatric manifestation of systemic lupus erythematosus (SLE). We aimed to characterize clinical patterns, electrophysiological subtypes, and outcomes in patients with concomitant SLE and GBS. Methods: We retrospectively reviewed two patients diagnosed with SLE‑associated GBS at our institution (2024–2025). A systematic PubMed search (January 2021–December 2025) identified published cases. Clinical characteristics, lupus activity, electrophysiological subtype, treatment, and outcomes were analyzed. Results: Thirteen published cases were identified. Combined with our two cases, 15 patients were analyzed. Most were young females (mean age ‑.32 years). GBS occurred concurrently with active SLE in nearly half of the cases. Axonal variants predominated (acute motor axonal neuropathy 40%, acute motor‑sensory axonal neuropathy [AMSAN] 33%), and AMSAN was consistently associated with incomplete recovery. Renal involvement was present in 80%, and most patients demonstrated serologic lupus activity. Management commonly required combined immunotherapy (intravenous immunoglobulin, corticosteroids, and plasma exchange), reflecting both neuropathic and systemic inflammatory components. Conclusions: GBS in SLE appears to represent an immune‑mediated peripheral neuropsychiatric lupus manifestation rather than a coincidental overlap. The predominance of axonal variants and association with active systemic disease underscores the importance of early electrophysiological evaluation and aggressive immunomodulatory therapy. |
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