增強型體外反搏系統（EECP）介入亞健康族群之健康影響

The Health Impact of Enhanced External Counterpulsation (EECP) Intervention on Sub-Healthy Populations

亞健康已成為現代快速生活步調與日益增加壓力下普遍的公共衛生問題。雖然未被列為明確的疾病，亞健康卻與生理功能下降、睡眠障礙及心理壓力密切相關，增加了罹患慢性病的風險。增強型體外反搏系統（EECP）過去常用於心血管疾病的輔助療法，但其對整體亞健康狀態的影響尚未明確。本研究探討EECP對年齡介於18至60歲之亞健康成人在心臟功能、腦血流、睡眠品質、荷爾蒙水平及心理健康的影響。參與者接受每週兩次或三次EECP治療，評估內容包括透過近紅外線光譜儀測量腦血流、分析唾液中的褪黑激素與皮質醇，以及使用經驗證的問卷（SCI、PSQI）評估健康狀態。研究使用廣義估計方程式（GEE）分析時間與組別的效應。研究發現接受超過五次EECP治療後出現顯著健康改善。生理方面，CMPB指標於治療次數超過五次後明顯提升。腦血流方面則呈現性別特異的模式：每週三次治療組的女性HEG Ratio較高，而男性則相反。睡眠品質方面，PSQI分數顯著下降、SCI分數明顯增加。褪黑激素水平受性別與治療頻率影響而有所差異。心理方面，WHO-5幸福指標分數提升，但皮質醇水準未呈顯著變化。社會層面，整體生活品質與SHSQ-25分數顯著改善，女性改善幅度尤為明顯。本研究結論指出，EECP能有效促進亞健康族群的身心健康，且累積治療次數比單週治療頻率更重要，並發現顯著的性別差異。未來研究建議擴大樣本規模，進一步探討性別與治療頻率對健康促進策略的影響。

Sub-health has become a widespread public health concern due to modern life's rapid pace and rising stress levels. Although not classified as a distinct disease, sub-health is linked to physiological decline, sleep disturbances, and psychological stress, increasing chronic illness risks. Enhanced External Counterpulsation (EECP), traditionally adjunctive cardiovascular therapy, has uncertain effects on overall sub-health.
This study evaluated EECP's effects on cardiac function, cerebral blood flow, sleep quality, hormonal levels, and psychological well-being in sub-healthy adults aged 18 to 60. Participants received EECP therapy either twice or three times weekly. Assessments included cerebral blood flow via near-infrared spectroscopy, salivary melatonin and cortisol, and validated questionnaires (SCI, PSQI, PROMIS-10, SHSQ-25). Generalized Estimating Equations (GEE) analyzed time and group effects.
Significant health improvements occurred after five EECP sessions. CMPB improved notably after exceeding five sessions. Cerebral blood flow showed gender-specific patterns: females had higher HEG Ratios with three weekly sessions, while males showed the opposite. Sleep quality significantly improved, with decreased PSQI scores and increased SCI scores. Melatonin levels differed by gender and intervention frequency. WHO-5 scores improved, although cortisol remained unchanged. Socially, quality of life and SHSQ-25 scores significantly increased, particularly among females.
The study concludes EECP effectively enhances physical and mental health in sub-healthy populations, emphasizing cumulative sessions over frequency, with significant gender differences noted. Future research should expand sample sizes and examine gender and frequency factors in health promotion strategies.