| 英文摘要 |
Climate change is profoundly reshaping the global landscape of infectious diseases and is altering both their distribution and transmission patterns. As global temperatures rise and extreme weather events, such as heatwaves, floods, and storms, increase in frequency and intensity, the ecological balance among pathogens, vectors, and hosts is progressively disrupted. One of the clearest examples is seen in mosquito-borne illnesses, such as dengue fever and Zika virus, whose primary vectors have begun expanding into higher latitudes and altitudes that were once considered unsuitable for their survival. This geographical shift highlights how warming temperatures and changing rainfall patterns can extend breeding seasons, thereby facilitating the proliferation of disease-carrying mosquitoes. Zoonotic diseases provide another stark illustration of the impact of climate change. Altered habitats and migratory routes for wildlife can allow pathogens to reach regions where they were previously unknown, often in areas with little local immunity or robust surveillance systems in place. As human encroachment on wildlife increases through urbanization and agricultural expansion, the interaction between humans and potential animal hosts intensifies, increasing the probability of new disease emergence. Moreover, shifts in precipitation extremes can lead to more frequent flooding, contaminating water supplies and accelerating the spread of waterborne pathogens, such as Vibrio species, Leptospira, and other bacteria and parasites. These microbial agents pose additional public health challenges, particularly in coastal and low-lying regions. Addressing these complex challenges requires coordinated cross-disciplinary efforts that merge climate science, epidemiological data, and public health expertise. A robust and responsive disease surveillance system is crucial. By integrating satellite-based remote sensing, geographic information systems, and real-time climate data, health authorities can detect early warning signs of an impending outbreak and respond proactively. For instance, identifying climatic patterns that favor mosquito breeding, such as a spike in rainfall followed by warm conditions, can help guide vector control efforts and vaccination campaigns toward high-risk areas before disease transmission intensifies. Therefore, healthcare systems must strengthen their capacity to manage climaterelated health emergencies. This includes reinforcing the clinical infrastructure, ensuring equitable distribution of emergency medical resources, and training personnel to respond effectively to surge events. On the technological front, advancements in genetic engineering-- including CRISPR-based strategies-- show promise for modifying vector populations to reduce their disease-carrying potential. Similarly, mRNA vaccine platforms have demonstrated remarkable versatility and rapid development timelines, as evidenced by recent successes in combating emerging pathogens. Ultimately, climate change exacerbates the threat of infectious diseases by reshaping ecosystems and altering interactions among humans, animals, and pathogens. Addressing this growing risk requires ongoing innovation in both epidemiological surveillance and biomedical research along with coordinated efforts among governments, scientists, healthcare providers, and local communities. By combining scientific insights with proactive health policies and cutting-edge biotechnology, societies can strengthen their resilience and minimize the social and economic impacts of climate-driven disease outbreaks. |