胰島素製劑的演進發展與臨床應用

The Development and Clinical Use of Insulin

自從1921年Banting醫師發現胰島素以來，胰島素不僅解救無數第1型糖尿患的生命，也成第2型糖尿患改善血糖控制的最後法寶，而胰島素製劑更是經歷多次演進，就來源，由原始的動物胰臟萃取物到高純度胰島素製劑，由人類胰島素至胰島素類似物；就作用時間而言，由短效而中長效，再由超速效型到目前甫上市的insulin glargine長效型；製劑種類型態感來感多，固然有利於糖尿病之控制，然對胰島素較生疏的臨床工作者則是一大挑戰，充份瞭解胰島素製劑，恪守臨床應用準則，是協助病患邁向優質血糖控制的不二法門。

Dr. Banting discovered insulin in 1921, not only rescuing the number of Type 1 diabet4es, but also improving Type 2 patients' blood sugar control. Insulin preparations have evolved dramatically over the past 60 years, characterized by species source-from the primitive animal pancreas to the highly purified insulin preaarations, and from the human insulin to human insulin analogue; and by time course of activity-from short-acting analog (just available in the year of 2000). The more kinds of insulin preparations, the more benefits for diabetes control are. Nevertheless more challenge for inexperienced clinical guidelines are necessary to lead patients into high quality glycemic control.