Although the issue about the US-China friction has been widely discussed, views about the impact by research institutions are diversifying, and there is little empirical study on individual industries. This article explores the economic impact of the US-China friction on Taiwan’s semiconductor and ICT (Information and Communication Technology) industry from 2017 to 2020. This paper uses the Computable General Equilibrium (CGE) model and Input-Output table to simulate the impact of the US-China friction on industries through in-depth interviews with industry experts. In the first stage, the Global Trade Analysis Project (GTAP) are used to analyze the impact of 10%~25% tariffs imposed by the United States and China on Taiwan’s macro-economy and the import and export prices of individual industries. Based on the results of the first stage and the opinions of industry experts, the second stage uses the General Equilibrium Model for Taiwanese Economy and Environment (GEMTEE) model to analyze the impact on Taiwan’s semiconductor and ICT industry. The simulation results show that the US-China friction will have a negative impact on Taiwan’s macro-economy, but the impact is much smaller than the estimates of some research institutions, which shows that Taiwanese manufacturers will benefit from the order transfer effect. However, when the tariff is increased to 25%, the order transfer effect will be largely offset by the impact of the global economic downturn, and the impact on the semiconductor industry will be greater than the impact on the ICT industry. To reduce the impact of the US-China friction on Taiwan’s industries, manufacturers should strive to diversify business risks, increase business flexibility and resilience, strengthen R&D to improve competitiveness, and introduce smart manufacturing to cope with the impact of US-China friction. The feature of this study is an emphasis on bottom-up research methods. Through repeated discussions with industry experts, the situation settings and parameter calibration are reviewed to make the simulation more reasonable and in line with practical conditions. Under the continued confrontation between the United States and China in the future, the result can be the reference direction for business operation adjustment.