Hyperphosphatemia is the one of most common problems in end-stage renal disease (ESRD) patients on maintenance hemodialysis. From July to December, 2017, there were 23.3% to 24.4% of hemodialysis patients whose serum phosphate values were ≥ 6.0 mg/ dl. The prevalence of hyperphosphatemia is higher than the standard value of 20% set by the Taiwan Society of Nephrology. Then we performed the root cause analysis and found the main problems: too many types of high-phosphorus foods, often confused with highpotassium foods, ignorance of hyperphosphatemia comorbidities, forgetting to take or carry drugs, lost nursing guidance leaflets; inconsistent content of nursing guidance, interruption of nursing guidance due to busy business, Not held group nursing guidance regularly. Thus, multidisciplinary approaches were implemented from January, 2018 as follows: developing nursing care guideline for hyperphosphatemia, holding continuing education programs for nurse and group educations for patients, using easily carry-on pill bottles and creating informative posters, mobile apps and animated videos for dietary phosphate education. After completing this project, the prevalence of hyperphosphatemia hemodialysis patients was declined from 25.5% to 18.5%. This project effectively lowered serum phosphate levels in hemodialysis patients and significantly improved the quality of nursing care for ESRD patients with hyperphosphatemia.