Prevention of falls is a key component promoting quality of care today. Most of the safety reports filed by this unit are fall events. In 2015, the hospital paid a huge compensation to a patient who suffered moderate injury due to a fall, and led to the formation of an ad hoc group to explore multiple strategies to reduce fall incidents in hemodialysis outpatients. After completing the analysis the following problems were found: limb weakness often occurs after dialysis, patient awareness regarding falls was inadequate, nurses neglect fall prevention measures, and poor design of the dialysis center. The following measures for improvement were implemented from May to December 2016: creation of electronic educational leaflets, revision and creation of e-assessment forms for operating standards of care, conduction of educational courses, designing and publication of exercise regimen during dialysis, removal of environmental risk factors, etc. Fall incidents fell from 8 to 1; awareness regarding fall prevention among hemodialysis outpatients increased from 63.6% to 90.3%; the completion rate of fall prevention measures by nursing staffs increased from 62.1% to 100%. Project goal was reached, and effectively improved patient safety and raised the quality of nursing care.