Purpose: The quality of diabetes care has been unsatisfactory overall in Taiwan and particularly substandard in rural areas where medical resources are relatively scarce. In response to the immense popularity of smart phones, the study aimed to assess the effectiveness of utilizing a mobile application (app) and cloud management for diabetes care in a rural public health center. Methods: Outpatients with diabetes monitored their blood glucose at home and input the data into the app to help their doctors give feedback on a cloud platform. Patients who did not use the app were suggested to upload the data to the platform using the smart cable at the public health center. Patients were regularly examined for glycated hemoglobin (HbA1c) for a period of 6 months. Medical records and platform data of the outpatients with type 2 diabetes were collected from September 1, 2016 to August 31, 2018. Nonparametric statistics were used to compare the differences between patients using app and no-app. Results: 18 patients completed the 6-month follow-up, with 8 using the app and 10 not. After the 6-month follow-up, drop in HbA1c was observed in both the app and no-app groups, and the number of data upload decreased from the first 3 months to the later three (p<0.05). Compared to their counterparts in the no-app group, patients in the app group were younger, with a higher level of education, a shorter duration of diabetes, and a greater improvement in HbA1c at the 6th month (p<0.05). Conclusion: Using a mobile app and cloud management for diabetes care in a rural public health center may help reduce HbA1c, but further studies are needed to investigate the long term effectiveness of this approach and how to apply it to the elderly.