Although Nusantara is located in the periphery of Islamic World, the spread and development of Islam in this region have been closely linked with that in the central lands, especially in the al-Jazīrat al-‘Arabiyyah region. After the entering of Islam into Nusantara, it took the shape of the so-called “Malay Islam” through localization, in which the interpretation of doctrines and ritual practices were distinguished from those in the central lands. During the 17th century, when the neo-Sufism was introduced to Nusanatar, some key reformist ‘Ulamā’ started launching reform of ‘Ibādah and Mu‘āmalah. They adopted the prevailing reform theories of neo-Sufism in the Ḥaramayn, i.e. Makkah and Madīnah to purify local Islamic traditions and Muslim mind. The aim of reform was to eliminate the local elements which had been imbedded into Muslim social lives, and to draw close relations with Islamic traditions of the central lands. This article essays to explore how the thoughts of neo-Sufism affected the development of Islam in pre-modern period Nusantara, and to reflect the relations between Islam in the central lands and that of periphery. Moreover, this article will show how the Islamic network functions in the spread of Islamic knowledge globally.