Large exhibitions hosting many different types of shows for vehicles, food, travel, books and specialized equipment ... etc. often gather a large crowd through displaying and selling various goods. In consideration of its substantial fire load and spaciousness which might easily lead to disaster in the case of fire development along with the impact of smoke cross-flow which inevitably hinders personnel safety in evacuation, fire safety has become a critical issue in such venues, which requires a breakthrough to traditional fire compartment. To make people in the exhibition center evacuate successfully, how to design the space and implement the effective evacuation plan so that people can evacuate to the safe place immediately and reduce the evacuation time are required. This study focuses on people evacuation and emergency evacuation routes in the large-scale exhibition centers during the exhibition periods. First, the study will take some major operational large-scale exhibition centers in domestic as research objects and use SIMULEX Evacuation Software, set related factors and parameters to carry out simulation and verification, comparing the evacuation time for different scenarios which developed based on literatures, field observations, comparative studies and information, in-depth interviews. Our research has discovered that the exhibition hall styles, the width and locations of entrances and exits, the planning of exhibition booth set up, the design of aisles (single-shaped, cross-shaped and square-shaped aisles) and widths and numbers of people it accommodates are all factors that will affect evacuation in case of emergency. Thus, it is recommended that from the management unit of the exhibition halls should reinforce self-protect fire-protection as well as implement safety management, could use this research as a reference.