For most Small and Medium size Enterprises (SME) which play the role of Original Equipment Manufacturers (OEM), it is not easy to build their own brand and develop innovative product due to limited resource. Since the blooming of cultural creative industry, it is opportunity but also challenge for the OEM-SME to develop cultural innovative product. The article uses a case study of the SHIOW YUH company to discuss the strategy and business model of cultural innovative product. We firstly introduce the Taiwan economic development stages to explain the evolution of the SHIOW YUH company from OEM oriented, technology research and development oriented, to cultural innovative product development oriented. Second, by analyzing the SHIOW YUH company case, we induce six product strategies for cultural innovative product and introduce the long-tail business model of the SHIOW YUH company. Finally, we extend our observations from the case study to construct a general business model for cultural innovation product. The results of this study could be useful for OEM-SME companies which hope to develop their own cultural innovative product.Nursing managers may provide training courses, relaxation courses, and support groups to gradually increase nurse conscientiousness and decrease nurse neuroticism to improve patient safety outcomes.