Ministry of Internal Affairs had Amended “Building Technical Regulations” related to provisions of accessible and usable buildings on October 1, 2012, which have improved the security regulations of preventing hook, hit, and falling of people with disabilities. This study analyzed the relevant regulations of domestic building fire prevention and accessible and usable buildings, and investigated weaknesses in evacuation regulations of people with disabilities. We tried to seek out a direction for improvement related to legislation through interviews with people with disabilities, fire experts, and professionals with accessible and usable field. This study found that when fires occur, people with disabilities who entered the building via an accessible and usable elevator could not use the accessible and usable elevator to escape and also could be unable to use stairs to escape by themselves, with potentially high risk. In future, evacuation elevators should be utilized to escape, while fire occurs, and refuge areas should be established in order to ensure the fire safety of people with disabilities. In addition, accessible pathways also need to have special guidance measures in emergency situations and a buffer refuge should be established, in order to ensure the safety of people with disabilities.