Campus open space is an important component of a modern university. University campus planning frequently emphasize hardware constructions so that these open spaces have been empty spaces after the plan is drawn up and treated as on comprehensive environmental developments with little consideration of the interactions among users. Universal design is an approach to creating usability by all people to the greatest extent possible in order to intensify friendly interactions among users and environments for planning and design disciplines. However, because application of universal design concepts mostly relies on subjective perceptions for priority evaluations, this paper claims a need for establishing an objective and comprehensive evaluation for planning and design in terms of university campus open spaces. Therefore, this paper integrated universal design principles concerning university campus open spaces through review of the literature, and generalized five major dimensions: constructiveness, humanity, security, availability and sustainability, comprising 51 possible influential factors. The Fuzzy Delphi method was applied to extract 15 explicit criteria in order to establish a comprehensive evaluation. The product performance program method was then adopted to examine the practical evaluation on an empirical case. The results show that the evaluation could be not only to the advantage of management improvement in the empirical campus, but to be a reference for evaluating university campus planning and design in the future.