| 中文摘要 |
目的：本研究的目的以描述性方式分析在安寧病房發生帶狀疹(herpes zoster)的個案，了解帶狀疹在安寧病房的流行病學及可能的危險因子，進而及早預防，以減輕病人因帶狀疹引起的併發症與不適。方法：本研究樣本為自2001年至2012年，曾經住過安寧病房，並發生過帶狀疹或曾經使用抗病毒藥物的癌末病人進行篩選，之後再藉由病歷回顧確認帶狀疹症狀出現日期為安寧病房住院期間，收集的資料包括：基本資料、住院及出院日期、帶狀疹症狀及診斷日期、死亡日期及出院診斷，以SAS 9.2套裝軟體做流行病學統計。結果：在研究期間，共有3,526位安寧病房住院個案，共57位符合篩選條件，最後有15位男性及6位女性病患經由病歷回顧確認在安寧病房住院期間罹患帶狀疹，總體的發生率為106.4人/1,000人*年，從性別來看，男性罹患帶狀疹的發生率較高，在年齡層方面，0-60歲有較高的發生率罹患帶狀疹。在危險因子方面，慢性腎衰竭和腎病變的個案，較容易罹患帶狀疹。結論：相較於台灣全體人口帶狀疹的發生率，安寧病房的癌症病人發生率高出許多，而且男女皆呈現小於60歲的族群發生率較高的趨勢。雖然，本研究顯示有慢性腎衰竭和腎病變的個案，較容易罹患帶狀疹，但是，每種共病症的個案數皆不多，無法代表安寧病房的癌症病人的危險因子，未來仍需要更大型的研究支持。 |
| 英文摘要 |
Background: This descriptive study investigated the incidence and risk factors of herpes zoster (HZ) among patients with advanced malignancy admitted to the hospice ward, for reducing associated patient discomfort and complications. Methods: We performed a retrospective study of patients diagnosed with advanced malignancy admitted to the hospice ward in Changhua Christian Hospital from 2001 to 2012. Included patients were either diagnosed with HZ or treated with anti-herpetic medication. Patients diagnosed with herpes simplex or admitted to the hospice ward due to other terminal conditions were excluded. Results: There were 15 men and 6 women infected with HZ in our hospice ward during the study period. All cases were confirmed via chart review. The general incidence of HZ was 106.4/1000 patient*years, with a higher incidence in male gender and in patients <60 years of age. In this study, chronic kidney disease was the most common risk factor for HZ among patients with advanced malignancy. Conclusions: Compared with the general population, patients admitted to the hospice ward due to malignancy had a higher incidence of HZ, irrespective of gender. Patients ≤60 years of age also had a higher incidence of HZ. Chronic kidney disease was an independent risk factor in advanced malignancy patients for developing HZ. Because of the small sample size, more studies are necessary to identify risk factors. |
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