| 中文摘要 |
Zinc pyrithione（以下簡稱Z.P）具有制菌、制徽作用，經常使用於皮脂溢性皮炎及頭皮屑，且效果非常顯著，本局鑒於其使用頻繁，乃主動抽購市售含Z.P之洗髮品，就其Z.P之含量，細胞毒性試驗及皮膚刺激性試驗方面加以分析，以了解其品質。Z.P含量測定部分，檢體以稀鹽酸溶解，稀釋至10 rg／m，依紫外光吸光度測定法逐件測試其吸收圖譜，並與同濃度之標準品比對，其最大吸收波長應在27442 m處呈現，並取其吸光值與標準品吸光值比對，以求得Z.P之含量。細胞毒性試驗方面，試驗細胞探10日齡之Chicken Embryo Primary Culture（簡稱CE cell），檢測濃度為0.1g in 10ml water，37°C，CO定溫箱經16～18小時後，以顯微鏡鏡檢。皮膚刺激性試驗方面，採2.5 kg家兔，以Draize氏貼布法進行檢驗。
Ninety-seven case samples of marketed shampoo in the Taiwan area were investigated to study the content of zinc pyrithione, cytotoxicity test and skin irritation test. Three of ninety-four. Samples (i.e. 3.09%) were found in violation after being analyzed by U.V. spectrometry. All of samples gave negative results in the cytotoxicity test. Due to the shortage of testing rabbits, only seventy-nine samples of different brands could be done for skin irritation test, in which thirteen cases (16.46%) gave positive results. |
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