| 英文摘要 |
The term diuretic was initially applied to the drugs that caused an increased excretion of urine. However, their therapeutical applications are not dependent on the excretion of water alone. The excretion of sodium is also important, for example, in the clinical treatment of edema'. For many years, both mercurial and thiazide diuretics exert their effects on electrolyte excretion by preventing the reabsorption of electrolyte from the kidney distal tubules. The mercurial diuretics are very potent but quite toxic and when thiazides are ingested, many patients become hypokalemia! Therefore, other potent diuretics with less toxicity are still sought. Physalis angulata ( B) (PA) and Staurogyne concinnula ( &) (SC) have been used in Taiwan as folk-medicines for the treatments of gout, edema and hypertension? The water extract of PA and SC have been shown with diuretic activity. In the present study, the diuretic score of PA (2 g/Kg P.O.) is 3.2 +0.7 in contrast to Hydroflumethiazide (5 mg/kg P.O.) 2.9 $ 0.5 (Table 1) and SC (5 g/kg P.O.) is 3.0 + 0.6 in contrast to Hydroflumethiazide (5 mg/kg P.O.) 3.8 2.4 (Table 2) respectively. |
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