壓電顯微切割系統之研製

Development of a Piezoelectric Micro-Cutting System

本研究目的是研製壓電超音波振動顯微切割系統，利用壓電致動器質量輕、體積小、反應快及出力大等優點，來推動切割器末端的刀具，進行高頻運動，致使刀具更易於刺入組織進行輪廓切割，以切割細胞組織為目的。為了使切割刀具能精準進行切割，利用影像處理方式，側向校準刀具至載台高度量，以線性平面步進馬達來改變移動組織被切割之速度，探討切割刀具振動幅值、頻率、改變切割速度等最佳的工作參數，以有效地減小切割阻力，研究結果顯示，切割洋蔥表皮細胞邊緣平整，可達降低設備成本，便於日後臨床之使用。

Micro dissection is used to obtain a particular kind of a single cell orcells from tissue sections such as cell oncogenes, tumor suppressor gensand enzymes. The purpose of this study is to establish a system based onpiezoelectric ultrasonic micro-tools and motion platform. Using ultrasonicvibrations, the micro-cut knife results in easy tissue penetration.Mechanical vision assists in monitoring the tool positioning and elucidatesthe feasibility of cutting. To determine the optimal parameters for dissection,the vibration amplitude and frequency of the cutting tool were studied.Resistance force due to micro dissection is reduced thereafter. Finally, alow cost device for micro dissection in clinical practice is achieved.